How does glial progesterone activate the neurons controlling GnRH neurons to induce the LH surge? Our working hypothesis is that kisspeptin-expressing neurons are activated by progesterone. Kisspeptin neurons have estradiol-induced progesterone receptors and potently stimulate GnRH neurons. We are currently examining the mechanism through which this glial–neuronal interaction mediates kisspeptin activation of GnRH neurons explaining estrogen positive feedback of the LH surge.
